Endocrine Abstracts

Introduction: Malignant pheocromocytomas are rare. Metastatic disease may be present at the time of diagnosis or may only be evident after. Prognosis is poor. Currently there is no effective cure.Case report: We describe the case of a 66-year-old woman with a history of pheocromocytoma submitted to left adrenalectomy in 1992. In the past 10 years, she complained of episodes of dorsal back pain associated with hypertensive peaks and tachycardia. In 4/2010...

KNDy neurons, which co-express kisspeptins, neurokinin B (NKB) and dynorphin (Dyn), play a key role in the tonic control of gonadotropin secretion by modulating the GnRH release. The assumed KNDy model proposes that NKB and Dyn (as stimulatory and inhibitory signals, respectively) auto-regulate the secretion of kisspeptins onto GnRH neurons. However, some aspects of this paradigm remain poorly defined. In this context, the aims of this work were to characterize i) the putative...

Background: Nonfunctioning pituitary adenomas are commonly diagnosed as large tumors. Most are detected incidentally during imaging studies. The aim of this study was to evaluate clinical presentation, characteristics and outcome of nonfunctioning pituitary macroadenomas incidentally (NFPMI) discovered.Methods: Twenty-seven patients (mean age 58.9 years, 45–82; 18 males:9 females) with NFPMI were studied. They represent 13.1% of NFPM followed in our...

The hypothalamic peptide, nesfatin-1, derived from the precursor NEFA/nucleobindin2 (NUCB2), was recently identified as central anorexigenic molecule, acting in a leptin-independent manner. Yet, its potential involvement in the regulation of other biological functions gated by body energy status remains unexplored. We show herein that NUCB2/nesfatin-1 is involved in the control of female puberty. NUCB2/nesfatin mRNA and protein were detected at the hypothalamus of pubertal fem...

It is now widely accepted that the kisspeptins (kps) and their receptor kiss1r play an essential role in the neuroendocrine regulation of the reproductive axis by stimulating hypothalamic GnRH secretion. However, kiss1 and kiss1r expression in tissues distinct from, but related to, the hypothalamus, prompted us to propose that these molecules may exert regulatory functions in additional places of the neuroendocrine system, such as the pituitary and two of its phy...

Familial hypocalciuria hypercalcemia (FHH) is an autossomal dominant condition caused by mutations in the calcium sensing receptor gene. It is characterized by moderate hypercalcemia, with normal or slightly elevated PTH levels and hypocalciuria secondary to the increased calcium reabsorption at the distal tubule level.We present a case report of a 16 year old patient, who was referred to our department at the age of 14 because of obesity (BMI: 36.9 K/m<...

Introduction: Gestational diabetes (DG) is associated with higher risk of diabetes mellitus (DM), and it’s recommended to perform an oral glucose tolerance test (OGTT) with 75 g after delivery to its reclassification. However, not all scientific societies recommend it.Aim: To evaluate glucose tolerance with OGTT after delivery in women with DG and the risk factors to glucose intolerance in glycaemia at 120′.Methods: Retr...

Introduction: Pituitary apoplexy (PA) is an endocrine emergency and usually presents with sudden headache and visual fields changes. Pituitary function assessment should be performed promptly and repeated throughout follow-up, regardless of the choice of treatment.Methods/design: Retrospective analysis of patients diagnosed with PA admitted to an Endocrinoloy Department of a tertiary hospital between 2002 and 2017. Review of patients’ medical record...

Background: The BSRTC aimed to standardize thyroid cytopathology reporting while enabling stratification of risk of malignancy (ROM) in thyroid nodules. Observational studies have demonstrated varying ROM for the Bethesda III and IV categories, further affected by the recent exemption of NIFTP. Finally, molecular testing is becoming a reasonable alternative for evaluating ROM in categories III and IV.Objective: To retrospectively establish the use of Bet...

Introduction: The definitive treatment of hyperthyroidism caused by toxic adenoma (TA) and toxic multinodular goiter (TMNG) is ablative therapy with radioactive iodine (RAI) or surgical resection of the hyperfunctioning thyroid nodules. Hypothyroidism after RAI therapy is a common complication.Objectives: To evaluate the prevalence and risk factors of hypothyroidism in patients undergoing RAI for AT and BMNT.Methods: A Multicentre ...